During this session a distinguished panel of infectious disease specialists reviews current clinical guidelines and evidence for metagenomic sequencing of microbial cell-free DNA. This session explores the critical questions of who to test, when to test, and why metagenomic sequencing—demonstrating how this innovative technology can enhance workflows and complement traditional approaches to infectious disease diagnostics. Drawing from their own experiences, our panelists share approaches to diagnostic stewardship, lessons in implementation, and compelling patient cases where metagenomic sequencing impacted clinical decision-making and patient outcomes.