Clinical Data

Clinical Study

Antimicrobial Stewardship & Healthcare Epidemiology

The effect of a plasma next-generation sequencing test on antimicrobial management in immunocompetent and immunocompromised patients—A single-center retrospective study

Some of the publications and abstracts listed on this page may reference the Karius Spectrum test under it's former name Karius Test. This product was rebranded to Karius Spectrum as of March 17, 2025.

Key Publications

Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients with Pneumonia: A Prospective Observational Study

Clinical Infectious Diseases (October 2023)

Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis

Journal of Clinical Microbiology (February 2023)

The effect of a plasma next-generation sequencing test on antimicrobial management in immunocompetent and immunocompromised patients - A single-center retrospective study

Cambridge University Press (February 2023)

Metagenomics in infectious disease diagnostics: Toward best-use practices to optimize actionable results

Transplant Infectious Disease (December 2022)

Cell-free next-generation sequencing impacts diagnosis and antimicrobial therapy in immunocompromised hosts: A retrospective study

Transplant Infectious Disease (January 2023)

Budget Impact of Microbial Cell-Free DNA Testing Using the Karius Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections

Applied Health Economics and Health Policy (September 2020)

Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia

Infectious Diseases Society of America (April 2021)

Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious diseases (SEP-SEQ, Nature Paper)

Nature Microbiology (February 2019)

Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays

Cambridge University Press - Infect Control Hosp Epidemiol (January 2026)

Disseminated BCGosis presenting as multiple intracranial lesions in an immunocompromised patient

Journal of Neuropathology & Experimental Neurology (December 2025)

Immune profiling in a living human recipient of a gene-edited pig kidney

Nature Medicine (January 2026)

Rapidly Developing Synchronous Mycotic Aneurysms of Thoracic Aorta and Subclavian Artery

Annals if Vascular Sirgery (January 2026)

A Fatal Convergence: HLH, Disseminated MAC, and Opportunistic Fungal Infections in an Immunocompromised Host

Infectious Diseases in Clinical Practice (January 2026)

Revealing Hidden Pathogens: Culture-Negative Vertebral Osteomyelitis Diagnosed via Plasma DNA Sequencing

Infectious Diseases in Clinical Practice (January 2026)

A Complex Case of Hemophagocytic Lymphohistiocytosis Secondary to Untreated Hepatitis C: Diagnostic Challenges

Journal of Hematology (December 2025)

Necrotizing Pneumonia Due to Blastomycosis: Diagnostic Challenges and the Emerging Role of Cell-Free DNA Testing

Journal of the American College of Cardiology (December 2025)

Multimodality Imaging of Intracardiac Lesions in a Lung Transplant Patient: Atypical Presentation of Culture-Negative Endocarditis