Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients with Pneumonia: A Prospective Observational Study
Clinical Infectious Diseases (October 2023)
Clinical Data
Clinical Study
Therapeutic Advances in Infectious Disease
Clinical utility of plasma microbial cell-free DNA sequencing in determining microbiologic etiology of infectious syndromes in solid organ transplant recipients
Some of the publications and abstracts listed on this page may reference the Karius Spectrum test under it's former name Karius Test. This product was rebranded to Karius Spectrum as of March 17, 2025.
Key Publications
Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis
Journal of Clinical Microbiology (February 2023)
The effect of a plasma next-generation sequencing test on antimicrobial management in immunocompetent and immunocompromised patients - A single-center retrospective study
Cambridge University Press (February 2023)
Metagenomics in infectious disease diagnostics: Toward best-use practices to optimize actionable results
Transplant Infectious Disease (December 2022)
Cell-free next-generation sequencing impacts diagnosis and antimicrobial therapy in immunocompromised hosts: A retrospective study
Transplant Infectious Disease (January 2023)
Budget Impact of Microbial Cell-Free DNA Testing Using the Karius Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections
Applied Health Economics and Health Policy (September 2020)
Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia
Infectious Diseases Society of America (April 2021)
Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious diseases (SEP-SEQ, Nature Paper)
Nature Microbiology (February 2019)
Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV
Pathogens and Immunity (February 2025)
From Chart Biopsy to Liquid Biopsy: Evaluating the Diagnostic Yield and Clinical Impact of Plasma Microbial Cell-Free DNA Next-Generation Sequencing in the Management of Fever of Unknown Origin
Open Forum Infectious Diseases (February 2025)
The utilization of microbial cell-free DNA next-generation sequencing for the detection of human herpesvirus-8 in a quaternary care center
Sage Journals - Therapeutic Advances in Infectious Disease (January 2025)
Evaluating the clinical utility of Aspergillus, Mucorales, and Nocardia bronchoalveolar PCRs for the diagnosis of invasive pulmonary infections in patients with hematological malignancies
Journal of Clinical Microbiology (January 2025)
Bartonella endocarditis-associated glomerulonephritis: a mimicker of autoimmunity and vasculitis
Kidney International Reports (January 2025)
Efficacy of microbial cell-free DNA testing for detecting pathogens in pediatric patients with head and neck infections—An initial study
Pediatric Investigation (January 2025)
Plasma Microbial Cell-Free DNA Sequencing for Diagnosis of Pediatric Lyme Disease
The Pediatric Infectious Disease Journal (December 2024)
A Committee-Based Diagnostic Stewardship Model for Pathogen Metagenomic Sequencing in Children
The Journal of Applied Laboratory Medicine (January 2025)
A one-year hospital system review of plasma next-generation sequencing in a mixed population
Antimicrobial Stewardship & Healthcare Epidemiology (November 2024)
Intracellular but not Undetectable: A Case of Francisella tularensis Pericarditis
ID Cases (December 2024)