Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients with Pneumonia: A Prospective Observational Study
Clinical Infectious Diseases (October 2023)
Clinical Data
Clinical Study
Therapeutic Advances in Infectious Disease
Clinical utility of plasma microbial cell-free DNA sequencing in determining microbiologic etiology of infectious syndromes in solid organ transplant recipients
Some of the publications and abstracts listed on this page may reference the Karius Spectrum test under it's former name Karius Test. This product was rebranded to Karius Spectrum as of March 17, 2025.
Key Publications
Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis
Journal of Clinical Microbiology (February 2023)
The effect of a plasma next-generation sequencing test on antimicrobial management in immunocompetent and immunocompromised patients - A single-center retrospective study
Cambridge University Press (February 2023)
Metagenomics in infectious disease diagnostics: Toward best-use practices to optimize actionable results
Transplant Infectious Disease (December 2022)
Cell-free next-generation sequencing impacts diagnosis and antimicrobial therapy in immunocompromised hosts: A retrospective study
Transplant Infectious Disease (January 2023)
Budget Impact of Microbial Cell-Free DNA Testing Using the Karius Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections
Applied Health Economics and Health Policy (September 2020)
Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia
Infectious Diseases Society of America (April 2021)
Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious diseases (SEP-SEQ, Nature Paper)
Nature Microbiology (February 2019)
Transmission of Ehrlichia chaffeensis From an Organ Donor to a Kidney–Pancreas Transplant Recipient
Images in Transplant Infectious Disease (2025) (September 2025)
Murine Typhus in Heart and Kidney Transplant Recipients: First Reported Cases Diagnosed by Microbial Cell-Free DNA Sequencing
Transplantation Proceedings (November 2025)
A rare case of Legionella bozemanae leading to necrotizing pneumonia in an immunocompromised patient: a case study
International Journal of Research in Medical Sciences (October 2025)
The Utility of Plasma Microbial Cell Free DNA Testing in the Diagnosis of Ureaplasma spp Infections: A Case Series
Consultant 360 (October 2025)
Atypical Presentation of Leptospirosis as Aseptic Meningitis in an Immunocompromised Patient: Impact of Rituximab on Recovery and Prolonged Inflammatory Response
Decoding the Unexpected: How Cell-Free DNA Sequencing Unveiled an Elusive Tularemia Case
The Permanente Journal (October 2025)
Travel-Related Malaria Diagnosis on Karius Test Despite Negative Blood Smear
Tropical Medicine and Infectious Disease (October 2025)
Culture-Negative Transcatheter Pulmonary Valve Endocarditis
Journal of the American College of Cardiology (JACC) Case Reports (October 2025)
Disseminated Histoplasmosis in Very Early Diagnosed De Novo STAT3-HIES
Journal of Clinical Immunology (October 2025)
A Case of Chronic Q Fever Treated With Doxycycline andTrimethoprim–Sulfamethoxazole With a Favorable Outcome
Case Reports in Infectious Diseases (September 2025)