The Karius HelionTM platform delivers rapid insights into how microbes impact health and disease with unparalleled efficiency. This technology platform is powered by three core elements.
Chemistry
Our “Direct-to-Library” process skips DNA extraction by preparing the sequencing library directly from the sample. By limiting hands-on time and building rigorous quality measures into every step, we minimize the potential for false positives or environmental contamination, which are typical challenges for metagenomic technology.
Database
Our continuously updated, clinical-grade database powers all Karius offerings, ensuring accurate microbial detection to support informed patient care. It contains over 20,000 references curated by our team of PhD biostatisticians, data engineers, and medical directors. Microbial cell-free DNA sequences from patient samples are compared to this database, which includes more than 1,000 human pathogens covered by our commercial plasma test.
Artificial Intelligence
Advanced machine learning algorithms allow analysis of complex genomic data in real time. Our proprietary reference genome databases are constantly refined as more data becomes available.