A liquid biopsy that avoids diagnostic impasse for
life-threatening infections.

Infections are one of the leading causes of morbidity and mortality in immunocompromised patients.

Order the Karius Test

Clinical Care

The main clinical application for the Karius Test is to help physicians diagnose infections in immunocompromised patients. The test helps diagnose pneumonia, invasive fungal infections, culture-negative endocarditis, opportunistic infections, and infectious causes of neutropenic fever.

Lab Services

The Karius Test provides you and your clinical team with the ability to use only a single blood draw to rapidly, and with high accuracy, detect more than 1000 clinically relevant pathogens.

A Rapid Liquid Biopsy for
Infectious Disease

The Karius Test is a liquid biopsy that can non-invasively and rapidly detect over 1000 pathogens causing both deep-seated and bloodstream infections from a single blood sample. The Karius Test helps clinicians avoid invasive, low-yield, and sequential diagnostic tests that can delay treatment for the most vulnerable hospitalized patients.

The main clinical application for the Karius Test is to help
physicians diagnose infections in immunocompromised patients

Invasive Fungal Infections
Infectious Causes of Neutropenic Fever
Opportunistic Infections

The Karius Test improves diagnosis and
management of life-threatening infections

Reduce complications from invasive procedures with 1 blood sample

The Karius Test requires 1 single blood draw to reveal information-rich, microbial cell–free DNA, potentially avoiding 63% of invasive diagnostic procedures.1

Speed up diagnosis of infections with a 1-day turnaround time

The Karius Test results typically report the next day after sample receipt, compared to standard methods, which can take days or weeks to yield results.

Optimize antimicrobial treatment

The Karius Test results have led to a change in antimicrobial management in 59%-75% of cases.2,3,4

Rapid, non-invasive detection
of 1000+ pathogens

Pathogen List

Comprehensive pathogen detection of over 1000 bacteria, DNA viruses, fungi, molds, and eukaryotes, including:

900+ Bacteria
400+ Fungi/Molds
100+ DNA Viruses
60+ Other Eukaryotes
1 Archaeon

Testing Process

From blood sample to report, the Karius Test process typically offers next day turnaround service.

View the Test Process

Clinical and Analytical Validation

Multiple published studies demonstrate the efficacy and clinical impact of
the Karius Test.

See Clinical Evidence

Frequently Asked Questions

From clinical situations to sample collection to interpretation of results, find more specific information about Karius and the Karius Test.

View FAQs

Improve the diagnosis of
life-threatening infections

The Karius Test has demonstrated higher diagnostic yield than the standard of care diagnostic tests in multiple studies.

Karius Test diagnostic yield



Standard tests diagnostic yield


Karius Test Process

Karius Test reports are typically available 1 day after specimen receipt*

The Karius laboratory is CLIA-certified and CAP-accredited to perform high-complexity clinical laboratory testing.

* >85% of specimens received by 8:30 AM (PT) Monday through Saturday are reported the next day.

Step 1

Specimen Collection

5-mL standard blood draw in plasma preparation tube

Step 2

Specimen Processing

DNA extraction and library preparation

Step 3


Microbial cell–free DNA sequencing

Step 4


Curated clinical-grade pathogen database

Step 5


Quantitative amounts of clinically relevant pathogens

Ordering the Karius Test

The Karius Test is a send-out test that can be ordered by hospital clinicians. The patient’s blood sample is collected at the hospital and shipped to the Karius laboratory overnight.

The kit includes:

  • Plasma preparation tube
  • Shipping materials
  • FedEx® Pak with preprinted label to Karius