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The Power of Microbial Cell-Free DNA: Real World Application of A Liquid Biopsy for Febrile Neutropenia

Use Case: Febrile Neutropenia

Speaker: Negar Ashouri, MD — Director, Antimicrobial Stewardship Chair, Infection Prevention Committee, Children's Hospital of Orange County

This webinar explores the application of metagenomic sequencing of plasma microbial cell-free DNA for the detection of pathogens associated with febrile neutropenia. The Karius Test, a liquid biopsy for infectious diseases, utilizes a single blood sample to identify over 1000 pathogens for various diagnostic purposes, including fever of unknown origin, invasive fungal infections, pneumonia, endocarditis, and febrile neutropenia. Our featured speaker, Dr. Negar Ashouri, reviews some of the published data and shares insights on the optimal use of the Karius Test for febrile neutropenia. Dr. Ashouri also shares some of her own patient cases describing the clinical impact of the Karius Test in febrile neutropenia.