Pneumonia in the ImmunoCompromised: Use of the Karius Test for the Detection of Undiagnosed Pathogens
Prospective, multi-center study comparing the Karius Test to Standard of Care in immunocompromised patients being evaluated for pneumonia
Pneumonia is the most common infectious cause of morbidity and significant mortality complicating bone marrow transplantation and treatment of hematologic malignancy1,2. Standard bronchoscopic and non-invasive microbiologic testing identifies a causative pathogen in less than half of cases.3, 4, 5, 6
Prospective, observational study, enrolling over 160 patients
Population: Immunocompromised adults with hematological malignancies or hematopoietic cell transplantation (HCT) with suspicion of pneumonia
- Duke University Health
- University of Pittsburgh Medical Center
- Fred Hutchinson Cancer Research Center
- MD Anderson Cancer Center
- City of Hope
- Tulane Medical Center
- University of California, San Francisco Medical Center
- University of Colorado Denver
- Weill Cornell Medicine
- Memorial Sloan Kettering Cancer Center
The Karius Test (KT) provided a 38.3% relative increase of the total diagnostic yield in conjunction with invasive and non-invasive standard of care (SOC) testing.
The Karius Test provided additive diagnostic value (ADV) by identifying the probable cause of pneumonia in 15.9% of immunocompromised patients via adjudication where SOC failed.
Highlights of organisms that the Karius Test identified which SOC missed:
- Rhizomucor pusillus
- Legionella micdadei
- Aspergillus fumigatus
- Pneumocystis jirovecii
Adding the Karius Test to the diagnostic workup for identifying causative pathogens in pneumonia improved diagnostic yield over SOC in patients with hematological malignancies or HCT.
Presented at IDWeekTM 2022
A preview of early results on the additive diagnostic value of the Karius Test when used in conjunction with SOC for the diagnosis of suspected pneumonia.
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- Certan M, et al. Clin Infect Dis. 2022;75(6):1046–1053
- Schuster MG, et al. Open Forum Infect Dis. 2017;4(2):ofx050
- Batra S et al. Pediatr Blood Cancer. 2015;62(9):1579-1586
- Bauer PR et al. Eur Respir J. 2019;54(1)
- Hofmeister CC et al. Bone Marrow Transplant. 2006;38(10):693-698
- Rano A et al. Thorax. 2001 May;56(5):379-87. doi: 10.1136/thorax.56.5.379.
- Bergin S, et al. 2022. PICKUP: Pneumonia in the ImmunoCompromised - Use of the Karius Test for detection of Undiagnosed Pathogens [Abstract]. IDWeek, 19-23 October, Washington, D.C