The Karius Test is a blood test based on metagenomic sequencing of plasma microbial cell-free DNA (mcfDNA) and utilizes a single blood sample to rapidly and non-invasively detect over 1000 pathogens associated with deep-seated and difficult-to-diagnose systemic infections. The Karius Test may help clinicians avoid many invasive, low-yield, and sequential diagnostic tests that can delay treatment for vulnerable hospitalized patients.
The Karius Test is designed to help physicians diagnose infectious in immunocompromised patients. The main diagnostic applications of the Karius Test include: pneumonia, febrile neutropenia, endocarditis, invasive fungal infections, and fever of unknown origin.
The Karius Test provides you and your clinical team with the ability to use asingle blood draw to rapidly detect more than 1000
pathogens.
The Karius Test has demonstrated higher diagnostic yield than the standard of care diagnostic tests in multiple studies.
85%
42%
80%
35%
92%
(63% invasive)
79%
(48% invasive)
80%
60%
71%
7% (Blood Culture only)
74%
53%
89%
26%
80%
30% (Blood Culture) / 50% (All)
The Karius Test results typically report the next day after sample receipt, compared with standard methods which can take days to weeks to yield results.5,6,8
Karius Test pathogen identification and the addition of genotypic bacterial antimicrobial resistance (AMR) detection may help clinicians to optimize antimicrobial treatment.3,4
The Karius Test requires a single blood draw to reveal information-rich, microbial cell-free DNA, potentially avoiding invasive diagnostic procedures.1,2
From blood sample to report, the Karius Test Process typically offers next day turnaround service.
Multiple published studies describe the analytical validation and clinical evidence of the Karius Test.
From clinical situations to sample collection to interpretation of results, find more specific information about Karius and Karius Test.
The Karius Test is a send-out test that can be ordered by hospital clinicians. The patient's blood sample is collected at the hospital and shipped to the Karius laboratory overnight.