Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients with Pneumonia: A Prospective Observational Study
Clinical Infectious Diseases (October 2023)
Clinical Data
Clinical Study
Therapeutic Advances in Infectious Disease
Clinical utility of plasma microbial cell-free DNA sequencing in determining microbiologic etiology of infectious syndromes in solid organ transplant recipients
Some of the publications and abstracts listed on this page may reference the Karius Spectrum test under it's former name Karius Test. This product was rebranded to Karius Spectrum as of March 17, 2025.
Key Publications
Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis
Journal of Clinical Microbiology (February 2023)
The effect of a plasma next-generation sequencing test on antimicrobial management in immunocompetent and immunocompromised patients - A single-center retrospective study
Cambridge University Press (February 2023)
Metagenomics in infectious disease diagnostics: Toward best-use practices to optimize actionable results
Transplant Infectious Disease (December 2022)
Cell-free next-generation sequencing impacts diagnosis and antimicrobial therapy in immunocompromised hosts: A retrospective study
Transplant Infectious Disease (January 2023)
Budget Impact of Microbial Cell-Free DNA Testing Using the Karius Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections
Applied Health Economics and Health Policy (September 2020)
Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia
Infectious Diseases Society of America (April 2021)
Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious diseases (SEP-SEQ, Nature Paper)
Nature Microbiology (February 2019)
A Systematic Literature Review to Determine Gaps in Diagnosing Suspected Infection in Solid Organ Transplant Recipients
Open Forum Infectious Diseases (January 2025)
Legionella maceachernii Pneumonia Presenting as a Cavitary Lesion in an Immunocompromised Patient
Cureus Journal of Medical Science (June 2025)
Delayed diagnosis of disseminated Mycobacterium intracellulare subsp. chimaera infective endocarditis via cell-free metagenomic next-generation sequencing: a case report
ASM Case Journals (May 2025)
Clinical Application of Metagenomic Next-Generation Sequencing of Microbial Cell-free DNA in Ruling Out Invasive Fungal Infection in a Patient with Thermal Burn Wounds: A Case Report
Journal of Burn Care & Research (May 2025)
Severe Capnocytophaga Canimorsus Purpura Fulminans After a Cat Bite in an Asplenic Patient: Diagnostic and Therapeutic Challenges
Cureus Journal of Medical Science (May 2025)
Disseminated Nocardiosis: Poorly Controlled Diabetes as an Immunocompromising State
Cureus Journal of Medical Science (May 2025)
The role of plasma metagenomic sequencing in identification of Balamuthia mandrillaris encephalitis
Acta Neuropathologica Communications (March 2025)
Illuminating the Challenges and Diagnostic Utility of Plasma Microbial Cell-Free DNA Sequencing in Suspected Infective Endocarditis: A Retrospective Observational Cohort Study
Open Forum Infectious Diseases (February 2025)
Plasma Microbial Cell-free DNA Sequencing for the Detection of Kingella kingae Pediatric Spinal Infections
The Pediatric Infectious Disease Journal (February 2025)
Chorioretinitis following Bacillus Calmette-Guerin Treatment for Bladder Cancer
Retinal Cases & Brief Reports (February 2025)