Karius

Transforming infectious disease diagnostics with genomics

We accurately identify 1,000+ pathogens from a single blood draw to help clinicians rapidly diagnose infectious diseases.

How it Works

1,000+ pathogens
Broad, quantitative coverage of bacteria, DNA viruses, fungi, and protozoa using next-generation sequencing

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Next day results
Sample-to-answer in a clinically
actionable timeframe

One test
Highly sensitive assay on a simple blood draw may spare patients unnecessary testing, antibiotic overuse, or invasive biopsies

.

Karius - IDWeekTM 2018 Highlights

 

 

“The Karius Test has helped us save childrens’ lives that might otherwise have been lost to infections.”

Dr. Lauge Farnaes, San Diego, CA
Pediatric Hematology/Oncology and Infectious Diseases Fellow

 

“The Karius Test is amazing. It’s going to completely change the way we diagnose and manage infectious diseases going forward.”

Dr. Ashah Shah, Stamford, CT
Infectious Diseases doctor

 

"The Karius Test saved my life by identifying the deadly strain of bacteria (Fusobacterium) that caused my life-threatening pneumonia."

Brian J
Read his full story here

Earlier Targeted Treatment for Sepsis

A 69-year-old male presented with sepsis and respiratory failure. Karius identified Mycobacterium tuberculosis from a plasma specimen the next day, while AFB culture from BAL fluid took 3 weeks to turn positive. The patient was able to start earlier multidrug treatment for pulmonary tuberculosis while discontinuing unnecessary antibiotics.

Invasive Fungal Infection in Immunocompromised Child

A 4-year-old girl with pre-B cell ALL presented with neutropenic fever. Karius testing identified Rhizopus oryzae after an extensive laboratory work-up for prolonged fevers came back negative. The patient ultimately underwent lung resection with tissue evaluation showing fungal elements, but she was able to initiate early antifungal treatment for invasive fungal infection prior to surgical intervention.

Comprehensive pathogen detection of over 1,000 bacteria, DNA viruses, fungi, molds and eukaryotes.

750+

Bacteria detected

Highlighted Bacteria:

Nocardia species (70)
Legionella species (20)
Rickettsia species (18)
Actinomyces species (14)
Mycoplasma species (8)
HACEK organisms (including Aggregatibacter actinomycetemcomitans,
Aggregatibacter aphrophilus,
Cardiobacterium hominis,
Eikenella corrodens,
Haemophilus parainfluenzae and
Kingella kingae)
Streptobacillus moniliformis
Mycobacterium tuberculosis complex
Mycobacterium avium complex (MAC)
Mycobacterium chimaera

How it Works

The Karius® Test is a send-out test that clinicians can order online. Detailed instructions for collecting and shipping specimens are available here.

PPT Tube
5 mL standard blood draw

dna

Specimen Processing
DNA extraction and library preparation

Sequencing
Pathogen DNA sequenced

dna analysis

Analysis
Curated clinical-grade microbe database

Report
Quantitative amounts of clinically relevant pathogens

The New World of Infectious Disease Diagnosis: Out in the Field with David Hong of Karius

Karius VP of Medical Affairs and Clinical Development Dr. David Hong recently appeared on a...

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Newly Published Case Series Demonstrates the Karius Test’s Effectiveness for Monitoring Infections in Stem-Cell Transplant Patients at Risk of Infections

 

Karius and Clinical Investigators from UCSF Showed that the Karius Test can Quickly and...

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Newly Published Case Series Demonstrates the Karius Test’s Effectiveness for Monitoring Infections in Stem-Cell Transplant Patients at Risk of Infections

 

Karius and Clinical Investigators from UCSF Showed that the Karius Test can Quickly and...

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Karius Medical Case Reports: Trypanosoma cruzi

 

Chagas Disease is an illness that affects 8 million people worldwide and is caused...

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Karius Secures $25 Million Additional Funding

 

Oxford Finance LLC, a specialty finance firm that provides senior debt to life sciences...

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Oxford Finance Provides $25 Million Senior Debt Facility to Karius, Inc.

 

Oxford Finance LLC, a specialty finance firm that provides senior debt to life sciences...

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Precision Medicine Looks beyond DNA Sequences

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Karius Announces the Clinical Investigator Award for Applied Pediatric Infectious Disease Genomics

 

Company to Award $50,000 in Clinical Research Grant Funds for Novel Applications of Pediatric...

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Karius Announces the Clinical Investigator Award for Applied Pediatric Infectious Disease Genomics

 

We are excited to announce this award for up to $50,000 in clinical research grant...

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Karius and Dasa enter into a partnership to introduce the Karius Test into Brazil

 

We are excited to announce that Karius is forming a partnership with Dasa, the largest...

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Karius and Dasa enter into a partnership to introduce the Karius Test, a quantitative next-generation sequencing blood test for infectious diseases, into Brazil

 

Karius is forming a partnership with Dasa, the largest medical diagnostic company in Latin America,...

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DNA Tests Could Help Docs Detect Infectious Diseases Faster

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Fever of Known Origins: Detecting Infections in Pediatrics with Plasma-based Next Generation Sequencing

 

This webinar focuses on applications of the Karius Test in pediatrics. Cases presented highlight diagnostic...

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Karius’ NGS test for infections shows high sensitivity in pilot study

 

The study, conducted with St. Jude Children's Research Hospital, showed a 78 percent predictive...

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Multiple Studies Presented at IDWeek 2018 Highlight Use of Karius Test as a Liquid Biopsy for Infectious Diseases

 

Academic collaborators presented results in challenging infectious disease applications including culture-negative endocarditis, predicting bloodstream...

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Karius and St. Jude Children’s Research Hospital Show that the Karius Test Might Predict Development of Bloodstream Infections in High-Risk Pediatric Cancer Patients

 

PREDSEQ Study Demonstrates the Promise of the Karius Test for Predicting Bloodstream Infections Prior...

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Karius and Duke Demonstrate that the Karius Test Accurately Detects and Quantifies Microbial Cell-free DNA in Patients with Infective Endocarditis

Karius is a venture-backed life science startup focused on transforming the way infectious diseases are...

Karius Announces Winners of the 2018 Clinical Investigator Awards

 

Two honorees receive a $50,000 grant to fund novel research using the Karius Test to...

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Karius and St. Jude Children’s Research Hospital Show that the Karius Test Might Predict Development of Bloodstream Infections in High-Risk Pediatric Cancer Patients

 

PREDSEQ Study Demonstrates the Promise of the Karius Test for Predicting Bloodstream Infections Prior...

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Karius Announces Winners of the 2018 Clinical Investigator Awards

 

Honorees will each receive a $50,000 grant to fund novel research using the Karius Test...

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Biotechnology Company Maps The Genome To Find The Dark Matter Of Infection

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Come Join Us for 7 IDWeek 2018 Abstracts

We're excited to announce that Karius collaborators will be presenting seven abstracts at the upcoming...

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A medical mystery that almost didn't get solved

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Analytical Validation of the Karius Microbial Cell-Free DNA Sequencing Test for Infectious Disease

In this webinar, Karius Co-Founder and Chief Scientific Officer Tim Blauwkamp presents results from the...

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Detecting invasive fungal infections with a liquid biopsy for infectious diseases

This webinar presents the results of a clinical study that showed how the Karius Test...

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How Karius Saved My Life: Brian’s Story

Dear Karius,

I am writing in heartfelt appreciation for the Karius Test, which...

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New Clinical Study Data Published on Karius Test in Patients with Invasive Fungal Infections

We are pleased to announce the positive results of a clinical study using blood samples...

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Diagnostic Microbiology and Infectious Disease Publishes New Clinical Study Data on Karius Test

Study Confirms Liquid Biopsy for Infectious Diseases Accurately Detects Invasive Fungal Infections

REDWOOD CITY, Calif. — ...

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Karius Medical Case Reports: Blood Culture-Negative Endocarditis

Blood culture-negative endocarditis is an infection of the heart valves where blood cultures to...

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Karius ASM Industry Showcase Webinar: Clinical Application of a Plasma Next-Generation Sequencing Test for Pathogen Detection

This talk was recorded at the ASM Microbe 2018 meeting on Saturday, June 9,...

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Deadline for Karius Clinical Investigator Awards Extended to July 13

This is the month to get your application in for the Karius Clinical...

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Karius to Present Data on The Karius Test at ASM Microbe 2018

Announces Newly Expanded, Comprehensive Genomic Diagnostic for Infectious  Diseases
Covering 1,320 Pathogens with a
...

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Karius Webinar: Introduction and Clinical Experience with the Karius Test

This is the first of a new webinar series about the clinical use of the...

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Fighting infectious disease with cfDNA

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Karius Announces Launch of Quantitative, Broad-Based Infectious Disease Diagnostic Test Using Microbial Cell-Free DNA

Test Detects and Quantifies DNA from Bacteria, Viruses and Fungi in a Single Blood...

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Karius Announces Launch of Quantitative, Broad-Based Infectious Disease Diagnostic Test Using Microbial Cell-Free DNA

Test Detects and Quantifies DNA from Bacteria, Viruses and Fungi in a Single Blood...

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Sequencing Comes to Infectious Diseases

We’re thrilled to be featured on the Mendelspod.com podcast today, featuring Karius CEO Dr. Mickey...

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Genomics soon to be standard for rapid ID diagnostics

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Karius Medical Case Reports: The Race to Diagnose Sepsis

Sepsis affects more than 1.5 million Americans annually, with about 250,000 of these patients dying...

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Karius Research: Detecting Pathogen DNA in Maternal Plasma

Intra-amniotic infections (IAI) can increase the risk of obstetric complications, including spontaneous onset of labor,...

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Pathogen Spotlight: Mucorales

Meet Mucor, a common mold in our environment that grows in soil and decaying organic matter....

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Announcing the Karius Clinical Investigator Awards for Applied Infectious Disease Genomics

Karius to Award $100,000 in Clinical Research Grant Funds for Novel Applications of Infectious Disease...

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Announcing the Karius Clinical Investigator Awards for Applied Infectious Disease Genomics

Karius to Award $100,000 in Clinical Research Grant Funds for Novel Applications of Infectious Disease...

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Nohla Therapeutics to Use Karius Pathogen Detection Test in AML Therapy Trial

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Karius Next-Generation Sequencing Blood Test for Infectious Disease Used in a Nohla Phase 2 Cellular Therapy Clinical Trial to Enable Detection of Subclinical Infections

REDWOOD CITY, Calif. - Karius, Inc., a life sciences company transforming infectious disease diagnostics with...

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Karius Test Used in a Nohla Phase 2 Clinical Trial for Detection of Subclinical Infections

REDWOOD CITY, Calif. – Karius, Inc., a life sciences company transforming infectious disease diagnostics with...

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Karius Medical Case Report: Secondary Infections After Influenza

Influenza has significantly altered the course of human history.

In the last 100 years, there...

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Karius Research: How to Advance Basic Science From Within Industry

Young scientists just starting out might have the perception that academic science makes all the...

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Karius Medical Case Report: Legionella pneumophila

Legionnaires’ disease is a severe form of pneumonia caused by the gram-negative bacterium Legionella pneumophila....

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Current Challenges in the World of Infectious Diseases

One of our greatest challenges is the continuing global impact of infectious diseases. Infections cause...

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Karius Medical Case Reports: Invasive Fungal Infections in Immunocompromised Patients

Invasive fungal infections (IFIs) are associated with significant morbidity and mortality in immunocompromised patient populations,...

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How a Child Inspired Me to Bring Microbial Cell-Free DNA Research from the Lab to the World

By Mickey Kertesz, PhD

As a new entrepreneur, I often get asked “Why...

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Karius and UCSF Show Rapid Pathogen Detection in Stem-Cell Transplant Patients

Trial Results Presented at American Society of Hematology Annual Meeting

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Karius Eyeing Sepsis, Transplant Patients as Key Markets for Infectious Disease Sequencing Test

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New Data Show Karius Test Improves Pathogen Detection in Challenging Patient Populations

Karius Presenting New Data From Five Abstracts at Infectious Disease Week Annual Meeting SEP-SEQ Trial...

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One Test May Spot Cancer, Infections, Diabetes and More

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Karius Spots $50 Million for Rapid Detection

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Karius Announces $50 Million in Financing for Technology Enabling Broad and Rapid Detection of Infectious Diseases

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Karius reels in $50M to ramp up infectious disease liquid biopsy

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Doctors say this start-up could revolutionize how we fight infectious diseases

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How Metagenomics Is Advancing Infectious Disease Diagnostics

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Source Code: Putting metagenomics to the test in the clinic

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Karius Aims to Diagnose Infection From Cell-Free Microbial DNA

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Karius Test Demonstrates Ability to Detect Pathogens from Cell-Free DNA Using Next-Generation Sequencing

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Karius, Inc. Announces Data Presentations and Informational Session at ASM Microbe 2017

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