Investigational Computational Biologist | Karius

Investigational Computational Biologist

Karius is a venture-backed life science startup focused on transforming the way infectious diseases are diagnosed.  Combining Next-Generation Sequencing and proprietary data analysis, we can identify over 1,000 pathogens from a single blood sample with typical turnaround time in one business day. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, with a future vision of accelerating clinical trials, discovering new microbes, and reducing patient suffering worldwide.

Position Summary:
We are seeking a candidate to work in a rapid, iterative research environment at the interface of our analytics, molecular biology, and medical teams. You will use rigorous quantitative reasoning to analyze and design experiments that allow us to understand more deeply, troubleshoot, and improve our existing and future assays. You will combine clinical and genomic data to gain novel insight into the interaction between pathogens and disease. This role sits at the heart of where important decisions are made about our technology, and a creative and energetic candidate will have the opportunity to shape the future of our assays and infectious disease medicine! 

Reports to: Manager, Computational Biology

Location: Redwood City, CA

Responsibilities Include:
·      Generate hypotheses, design experiments, and glean insights that improve the understanding of the genomic signatures of pathogen infection
·      Design and implement algorithms and statistical and machine learning models to drive discovery and interpretation using genomic, metagenomic, and other kinds of biological and clinical data
·      Produce robust, reproducible research findings out of multiple sources of heterogeneous data
·      Collaborate with the scientists, physicians, and engineers to make meaningful contributions to scientific discoveries and the invention of technologies·      


Physical Requirements:
·      Subject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is performed in an office environment.

Position Requirements:
·      PhD in computational biology, statistics, or related fields.
·      0-2 years of post-graduate experience.
·      Demonstrated expertise in analysis and visualization of biological data to drive insight and decision-making.
·      Experience with and understanding of modern statistics and/or machine learning.
·      Familiarity and experience with bioinformatics tools, approaches and workflows, particularly those related to next-generation sequencing data analysis.
·      Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).
·      Proficiency in working with large-scale datasets in Python or R.
·      Creativity in generating hypotheses and proposing experiments and analyses to test them.
·      Excellence at communication and collaboration within a cross-functional team.

At Karius, we value a diverse and inclusive workplace and provide equal employment opportunity for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company.  All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at and we will accommodate qualified individuals with disabilities.

Redwood City, CA