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Liquid Biopsy for Infectious Diseases in the Immunocompromised Patients


The Karius® Test can assist clinicians by non-invasively detecting from a single blood draw over 1,000 bacteria, fungi, and DNA viruses causing respiratory or other infections, typically within one day of sample receipt.a,b  The Karius Test does not detect SARS-CoV-2, and diagnosis of an alternative respiratory infection does not rule out infection with SARS-CoV-2.



Common Use Cases

  • Deep Seated Infection

  • Severe Community Acquired Pneumonia


Anticipated Benefits During COVID-19

  • Potential to shorten the time at the hospital

  • Reduce COVID-19 exposure and transmission risk through non-invasive testing

Learn more about the clinical and analytical validation of the Karius Test as published in Nature Microbiology.1


Contact a Karius
infectious disease physician

Frequently Asked Questions


  1. Can the Karius Test detect SARS-CoV-2? 

    No. The Karius Test cannot detect RNA viruses such as SARS-CoV-2. The list of 1,000+ detectable pathogens can be found here: kariusdx.com/pathogenlist.


  1. Does a positive Karius Test result rule out COVID-19?

    No. The diagnosis of an alternative respiratory infection does not rule out infection with SARS-CoV-2. As with any diagnostic test, the Karius Test results should be interpreted within the context of clinical data, including patient history, physical findings, epidemiological risk factors, and other laboratory data.

    Our Medical Affairs team of infectious diseases physicians is available for consultation. Please contact Medical Affairs at medical@kariusdx.com or 866-452-7487.


  1. Does prior antimicrobial therapy influence Karius Test results?

    The Karius Test can detect cell-free DNA (cfDNA) from dead and dying pathogens released into the bloodstream. Therefore, the cfDNA signal of a pathogen may still be detected even when a patient has been pre-treated with antibiotics


  1. What is the Karius Test process?

    The Karius Test is a simple and efficient process. One 5 mL blood sample should be collected in a plasma preparation tube (PPT), centrifuged at your hospital, and then shipped overnight to Karius. Karius Test kits, which include collection tubes and shipping supplies, are supplied by Karius. Results are typically reported one day after sample receipt.


  1. How will my institution receive the Karius Test result?

    All Karius Test results are faxed to the fax number provided during account setup. Additionally, test results can be accessed via online portal or SMS. Please call Karius Customer Support for assistance with these alternative methods of receiving test results.


For additional questions, please contact Karius Customer Support (Phone: 866-452-7487 | Email: help@kariusdx.com). We are available 24/7.